The railway station Santa Lucia is connected to the rest of Italy with Eurostar trains, Intercities and Interregional and local trains.
Inside the station there are trolleys for your luggage which can be taken up to the waterbus stop by using the side exit of the station, thus avoiding the steps outside the main exit.
You can leave your luggages at the left luggage office (near platform 14), open daily from 6am to midnight. If you need help transporting your luggage in Venice, you can phone the Cooperativa Trasbagagli (phone +390415203070). Once you are out of the train station, you can decide to begin your city tour on foot or by waterbus.

For detailed information on train timetables and ticket prices you can check the italian Railways website: www.trenitalia.it